strain background ( m. musculus ) , dat-cre Search Results


dat cre  (Jackson Laboratory)
86
Jackson Laboratory dat cre
Dat Cre, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/strain+background+(+m%2E+musculus+)+%2C+dat-cre/cre+dat+mice/pmc12707814-1-8-14
Average 86 stars, based on 1 article reviews
dat cre - by Bioz Stars, 2026-10
86/100 stars
  Buy from Supplier
vgat ires cre stock no 028862 mice  (Jackson Laboratory)
86
Jackson Laboratory vgat ires cre stock no 028862 mice
Vgat Ires Cre Stock No 028862 Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/strain+background+(+m%2E+musculus+)+%2C+dat-cre/cre+vgat/pm41944312-334-7-15
Average 86 stars, based on 1 article reviews
vgat ires cre stock no 028862 mice - by Bioz Stars, 2026-10
86/100 stars
  Buy from Supplier
emx1 cre mice  (Jackson Laboratory)
86
Jackson Laboratory emx1 cre mice
Serotonin 5-HT 2A R in DRG neurons represses oxycodone-induced antinociception in male mice. ( A ) Restoration of 5-HT 2A R expression in DRG neurons of 5-HT 2A R −/− male mice. By insertion of a “stop” cassette 5’ upstream of exon 1 (grey box) flanked by loxP sites (red arrows), we interrupted the translation of the 5-HT 2A R gene. Pirt-Cre excises the stop cassette and restores expression of 5-HT 2A R to areas where their promoter activities overlap. ( B ) Representative immunohistochemical images with anti-5-HT 2A R antibody and HRP-conjugated secondary antibody in DRG tissue samples of 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice. Note that 5-HT 2A R immunoreactivity is rescued in the DRG of 5-HT 2A R −/− :Pirt-Cre male mice. ( C ) Adjunctive effect of volinanserin (0.125 mg/kg) or vehicle on the cumulative dose-response induced by oxycodone in the TFR test in male 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice (n = 10-12 mice per group) (Oxycodone effect F[7,244] = 90.34, p < 0.001, Volinanserin/Genotype effect F[4,244] = 6.90, p < 0.01). ( D and E ) Male 5-H 2A R −/− <t>:Emx1-Cre</t> , 5-HT 2A R −/− :DAT-Cre and 5-HT 2A R −/− mice were given oxycodone (8 mg/kg), volinanserin (0.125 mg/kg) and oxycodone, or vehicle once a day for 5 days, after which locomotor activity was evaluated. On day 8 (3 days after the last injection), all mice received a single dose of oxycodone (8 mg/kg), and then tested for locomotor activity (n = 9-20 mice per group). Two-way ANOVA ( D – days 0-5, Time effect F[5,522] = 24.44, p < 0.001, Volinanserin/Oxycodone/Genotype effect F[5,522] = 39.77, p < 0.001) or one-way ANOVA ( D – day 8 and E , F[6,85] = 9.45, p < 0.001) followed by Bonferroni’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, n.s., not significant. Data are mean ± S.E.M.
Emx1 Cre Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/strain+background+(+m%2E+musculus+)+%2C+dat-cre/cre+emx1+mice/pmc08934299-49-24-42
Average 86 stars, based on 1 article reviews
emx1 cre mice - by Bioz Stars, 2026-10
86/100 stars
  Buy from Supplier
female wildtype c57bl 6 mice  (Charles River Laboratories)
86
Charles River Laboratories female wildtype c57bl 6 mice
Serotonin 5-HT 2A R in DRG neurons represses oxycodone-induced antinociception in male mice. ( A ) Restoration of 5-HT 2A R expression in DRG neurons of 5-HT 2A R −/− male mice. By insertion of a “stop” cassette 5’ upstream of exon 1 (grey box) flanked by loxP sites (red arrows), we interrupted the translation of the 5-HT 2A R gene. Pirt-Cre excises the stop cassette and restores expression of 5-HT 2A R to areas where their promoter activities overlap. ( B ) Representative immunohistochemical images with anti-5-HT 2A R antibody and HRP-conjugated secondary antibody in DRG tissue samples of 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice. Note that 5-HT 2A R immunoreactivity is rescued in the DRG of 5-HT 2A R −/− :Pirt-Cre male mice. ( C ) Adjunctive effect of volinanserin (0.125 mg/kg) or vehicle on the cumulative dose-response induced by oxycodone in the TFR test in male 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice (n = 10-12 mice per group) (Oxycodone effect F[7,244] = 90.34, p < 0.001, Volinanserin/Genotype effect F[4,244] = 6.90, p < 0.01). ( D and E ) Male 5-H 2A R −/− <t>:Emx1-Cre</t> , 5-HT 2A R −/− :DAT-Cre and 5-HT 2A R −/− mice were given oxycodone (8 mg/kg), volinanserin (0.125 mg/kg) and oxycodone, or vehicle once a day for 5 days, after which locomotor activity was evaluated. On day 8 (3 days after the last injection), all mice received a single dose of oxycodone (8 mg/kg), and then tested for locomotor activity (n = 9-20 mice per group). Two-way ANOVA ( D – days 0-5, Time effect F[5,522] = 24.44, p < 0.001, Volinanserin/Oxycodone/Genotype effect F[5,522] = 39.77, p < 0.001) or one-way ANOVA ( D – day 8 and E , F[6,85] = 9.45, p < 0.001) followed by Bonferroni’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, n.s., not significant. Data are mean ± S.E.M.
Female Wildtype C57bl 6 Mice, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/strain+background+(+m%2E+musculus+)+%2C+dat-cre/balb+c+mice/bio_rxiv__2025__10__23__683697-194-2-6
Average 86 stars, based on 1 article reviews
female wildtype c57bl 6 mice - by Bioz Stars, 2026-10
86/100 stars
  Buy from Supplier
floxed tdtomato mice  (Jackson Laboratory)
86
Jackson Laboratory floxed tdtomato mice
Serotonin 5-HT 2A R in DRG neurons represses oxycodone-induced antinociception in male mice. ( A ) Restoration of 5-HT 2A R expression in DRG neurons of 5-HT 2A R −/− male mice. By insertion of a “stop” cassette 5’ upstream of exon 1 (grey box) flanked by loxP sites (red arrows), we interrupted the translation of the 5-HT 2A R gene. Pirt-Cre excises the stop cassette and restores expression of 5-HT 2A R to areas where their promoter activities overlap. ( B ) Representative immunohistochemical images with anti-5-HT 2A R antibody and HRP-conjugated secondary antibody in DRG tissue samples of 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice. Note that 5-HT 2A R immunoreactivity is rescued in the DRG of 5-HT 2A R −/− :Pirt-Cre male mice. ( C ) Adjunctive effect of volinanserin (0.125 mg/kg) or vehicle on the cumulative dose-response induced by oxycodone in the TFR test in male 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice (n = 10-12 mice per group) (Oxycodone effect F[7,244] = 90.34, p < 0.001, Volinanserin/Genotype effect F[4,244] = 6.90, p < 0.01). ( D and E ) Male 5-H 2A R −/− <t>:Emx1-Cre</t> , 5-HT 2A R −/− :DAT-Cre and 5-HT 2A R −/− mice were given oxycodone (8 mg/kg), volinanserin (0.125 mg/kg) and oxycodone, or vehicle once a day for 5 days, after which locomotor activity was evaluated. On day 8 (3 days after the last injection), all mice received a single dose of oxycodone (8 mg/kg), and then tested for locomotor activity (n = 9-20 mice per group). Two-way ANOVA ( D – days 0-5, Time effect F[5,522] = 24.44, p < 0.001, Volinanserin/Oxycodone/Genotype effect F[5,522] = 39.77, p < 0.001) or one-way ANOVA ( D – day 8 and E , F[6,85] = 9.45, p < 0.001) followed by Bonferroni’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, n.s., not significant. Data are mean ± S.E.M.
Floxed Tdtomato Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/strain+background+(+m%2E+musculus+)+%2C+dat-cre/conditional+dicer+knockout+strain/pmc12480473-196-22-24
Average 86 stars, based on 1 article reviews
floxed tdtomato mice - by Bioz Stars, 2026-10
86/100 stars
  Buy from Supplier
strain background  (Jackson Laboratory)
86
Jackson Laboratory strain background
Serotonin 5-HT 2A R in DRG neurons represses oxycodone-induced antinociception in male mice. ( A ) Restoration of 5-HT 2A R expression in DRG neurons of 5-HT 2A R −/− male mice. By insertion of a “stop” cassette 5’ upstream of exon 1 (grey box) flanked by loxP sites (red arrows), we interrupted the translation of the 5-HT 2A R gene. Pirt-Cre excises the stop cassette and restores expression of 5-HT 2A R to areas where their promoter activities overlap. ( B ) Representative immunohistochemical images with anti-5-HT 2A R antibody and HRP-conjugated secondary antibody in DRG tissue samples of 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice. Note that 5-HT 2A R immunoreactivity is rescued in the DRG of 5-HT 2A R −/− :Pirt-Cre male mice. ( C ) Adjunctive effect of volinanserin (0.125 mg/kg) or vehicle on the cumulative dose-response induced by oxycodone in the TFR test in male 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice (n = 10-12 mice per group) (Oxycodone effect F[7,244] = 90.34, p < 0.001, Volinanserin/Genotype effect F[4,244] = 6.90, p < 0.01). ( D and E ) Male 5-H 2A R −/− <t>:Emx1-Cre</t> , 5-HT 2A R −/− :DAT-Cre and 5-HT 2A R −/− mice were given oxycodone (8 mg/kg), volinanserin (0.125 mg/kg) and oxycodone, or vehicle once a day for 5 days, after which locomotor activity was evaluated. On day 8 (3 days after the last injection), all mice received a single dose of oxycodone (8 mg/kg), and then tested for locomotor activity (n = 9-20 mice per group). Two-way ANOVA ( D – days 0-5, Time effect F[5,522] = 24.44, p < 0.001, Volinanserin/Oxycodone/Genotype effect F[5,522] = 39.77, p < 0.001) or one-way ANOVA ( D – day 8 and E , F[6,85] = 9.45, p < 0.001) followed by Bonferroni’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, n.s., not significant. Data are mean ± S.E.M.
Strain Background, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/strain+background+(+m%2E+musculus+)+%2C+dat-cre/background+strain/10__7554_slash_elife__102308__3-312-10-19
Average 86 stars, based on 1 article reviews
strain background - by Bioz Stars, 2026-10
86/100 stars
  Buy from Supplier
strain  (Jackson Laboratory)
86
Jackson Laboratory strain
Serotonin 5-HT 2A R in DRG neurons represses oxycodone-induced antinociception in male mice. ( A ) Restoration of 5-HT 2A R expression in DRG neurons of 5-HT 2A R −/− male mice. By insertion of a “stop” cassette 5’ upstream of exon 1 (grey box) flanked by loxP sites (red arrows), we interrupted the translation of the 5-HT 2A R gene. Pirt-Cre excises the stop cassette and restores expression of 5-HT 2A R to areas where their promoter activities overlap. ( B ) Representative immunohistochemical images with anti-5-HT 2A R antibody and HRP-conjugated secondary antibody in DRG tissue samples of 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice. Note that 5-HT 2A R immunoreactivity is rescued in the DRG of 5-HT 2A R −/− :Pirt-Cre male mice. ( C ) Adjunctive effect of volinanserin (0.125 mg/kg) or vehicle on the cumulative dose-response induced by oxycodone in the TFR test in male 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice (n = 10-12 mice per group) (Oxycodone effect F[7,244] = 90.34, p < 0.001, Volinanserin/Genotype effect F[4,244] = 6.90, p < 0.01). ( D and E ) Male 5-H 2A R −/− <t>:Emx1-Cre</t> , 5-HT 2A R −/− :DAT-Cre and 5-HT 2A R −/− mice were given oxycodone (8 mg/kg), volinanserin (0.125 mg/kg) and oxycodone, or vehicle once a day for 5 days, after which locomotor activity was evaluated. On day 8 (3 days after the last injection), all mice received a single dose of oxycodone (8 mg/kg), and then tested for locomotor activity (n = 9-20 mice per group). Two-way ANOVA ( D – days 0-5, Time effect F[5,522] = 24.44, p < 0.001, Volinanserin/Oxycodone/Genotype effect F[5,522] = 39.77, p < 0.001) or one-way ANOVA ( D – day 8 and E , F[6,85] = 9.45, p < 0.001) followed by Bonferroni’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, n.s., not significant. Data are mean ± S.E.M.
Strain, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/strain+background+(+m%2E+musculus+)+%2C+dat-cre/strain/pmc12380431-38-0-13
Average 86 stars, based on 1 article reviews
strain - by Bioz Stars, 2026-10
86/100 stars
  Buy from Supplier
strain background  (Charles River Laboratories)
86
Charles River Laboratories strain background
Serotonin 5-HT 2A R in DRG neurons represses oxycodone-induced antinociception in male mice. ( A ) Restoration of 5-HT 2A R expression in DRG neurons of 5-HT 2A R −/− male mice. By insertion of a “stop” cassette 5’ upstream of exon 1 (grey box) flanked by loxP sites (red arrows), we interrupted the translation of the 5-HT 2A R gene. Pirt-Cre excises the stop cassette and restores expression of 5-HT 2A R to areas where their promoter activities overlap. ( B ) Representative immunohistochemical images with anti-5-HT 2A R antibody and HRP-conjugated secondary antibody in DRG tissue samples of 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice. Note that 5-HT 2A R immunoreactivity is rescued in the DRG of 5-HT 2A R −/− :Pirt-Cre male mice. ( C ) Adjunctive effect of volinanserin (0.125 mg/kg) or vehicle on the cumulative dose-response induced by oxycodone in the TFR test in male 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice (n = 10-12 mice per group) (Oxycodone effect F[7,244] = 90.34, p < 0.001, Volinanserin/Genotype effect F[4,244] = 6.90, p < 0.01). ( D and E ) Male 5-H 2A R −/− <t>:Emx1-Cre</t> , 5-HT 2A R −/− :DAT-Cre and 5-HT 2A R −/− mice were given oxycodone (8 mg/kg), volinanserin (0.125 mg/kg) and oxycodone, or vehicle once a day for 5 days, after which locomotor activity was evaluated. On day 8 (3 days after the last injection), all mice received a single dose of oxycodone (8 mg/kg), and then tested for locomotor activity (n = 9-20 mice per group). Two-way ANOVA ( D – days 0-5, Time effect F[5,522] = 24.44, p < 0.001, Volinanserin/Oxycodone/Genotype effect F[5,522] = 39.77, p < 0.001) or one-way ANOVA ( D – day 8 and E , F[6,85] = 9.45, p < 0.001) followed by Bonferroni’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, n.s., not significant. Data are mean ± S.E.M.
Strain Background, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/strain+background+(+m%2E+musculus+)+%2C+dat-cre/background+strain/10__7554_slash_elife__105271-238-13-19
Average 86 stars, based on 1 article reviews
strain background - by Bioz Stars, 2026-10
86/100 stars
  Buy from Supplier
bupivicaine  (Sintetica SA)
90
Sintetica SA bupivicaine
Serotonin 5-HT 2A R in DRG neurons represses oxycodone-induced antinociception in male mice. ( A ) Restoration of 5-HT 2A R expression in DRG neurons of 5-HT 2A R −/− male mice. By insertion of a “stop” cassette 5’ upstream of exon 1 (grey box) flanked by loxP sites (red arrows), we interrupted the translation of the 5-HT 2A R gene. Pirt-Cre excises the stop cassette and restores expression of 5-HT 2A R to areas where their promoter activities overlap. ( B ) Representative immunohistochemical images with anti-5-HT 2A R antibody and HRP-conjugated secondary antibody in DRG tissue samples of 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice. Note that 5-HT 2A R immunoreactivity is rescued in the DRG of 5-HT 2A R −/− :Pirt-Cre male mice. ( C ) Adjunctive effect of volinanserin (0.125 mg/kg) or vehicle on the cumulative dose-response induced by oxycodone in the TFR test in male 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice (n = 10-12 mice per group) (Oxycodone effect F[7,244] = 90.34, p < 0.001, Volinanserin/Genotype effect F[4,244] = 6.90, p < 0.01). ( D and E ) Male 5-H 2A R −/− <t>:Emx1-Cre</t> , 5-HT 2A R −/− :DAT-Cre and 5-HT 2A R −/− mice were given oxycodone (8 mg/kg), volinanserin (0.125 mg/kg) and oxycodone, or vehicle once a day for 5 days, after which locomotor activity was evaluated. On day 8 (3 days after the last injection), all mice received a single dose of oxycodone (8 mg/kg), and then tested for locomotor activity (n = 9-20 mice per group). Two-way ANOVA ( D – days 0-5, Time effect F[5,522] = 24.44, p < 0.001, Volinanserin/Oxycodone/Genotype effect F[5,522] = 39.77, p < 0.001) or one-way ANOVA ( D – day 8 and E , F[6,85] = 9.45, p < 0.001) followed by Bonferroni’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, n.s., not significant. Data are mean ± S.E.M.
Bupivicaine, supplied by Sintetica SA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/strain+background+(+m%2E+musculus+)+%2C+dat-cre/bupivacaine/10__7554_slash_elife__72240-334-38-40
Average 90 stars, based on 1 article reviews
bupivicaine - by Bioz Stars, 2026-10
90/100 stars
  Buy from Supplier
clozapine-noxide (cno  (Enzo Biochem)
90
Enzo Biochem clozapine-noxide (cno
Serotonin 5-HT 2A R in DRG neurons represses oxycodone-induced antinociception in male mice. ( A ) Restoration of 5-HT 2A R expression in DRG neurons of 5-HT 2A R −/− male mice. By insertion of a “stop” cassette 5’ upstream of exon 1 (grey box) flanked by loxP sites (red arrows), we interrupted the translation of the 5-HT 2A R gene. Pirt-Cre excises the stop cassette and restores expression of 5-HT 2A R to areas where their promoter activities overlap. ( B ) Representative immunohistochemical images with anti-5-HT 2A R antibody and HRP-conjugated secondary antibody in DRG tissue samples of 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice. Note that 5-HT 2A R immunoreactivity is rescued in the DRG of 5-HT 2A R −/− :Pirt-Cre male mice. ( C ) Adjunctive effect of volinanserin (0.125 mg/kg) or vehicle on the cumulative dose-response induced by oxycodone in the TFR test in male 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice (n = 10-12 mice per group) (Oxycodone effect F[7,244] = 90.34, p < 0.001, Volinanserin/Genotype effect F[4,244] = 6.90, p < 0.01). ( D and E ) Male 5-H 2A R −/− <t>:Emx1-Cre</t> , 5-HT 2A R −/− :DAT-Cre and 5-HT 2A R −/− mice were given oxycodone (8 mg/kg), volinanserin (0.125 mg/kg) and oxycodone, or vehicle once a day for 5 days, after which locomotor activity was evaluated. On day 8 (3 days after the last injection), all mice received a single dose of oxycodone (8 mg/kg), and then tested for locomotor activity (n = 9-20 mice per group). Two-way ANOVA ( D – days 0-5, Time effect F[5,522] = 24.44, p < 0.001, Volinanserin/Oxycodone/Genotype effect F[5,522] = 39.77, p < 0.001) or one-way ANOVA ( D – day 8 and E , F[6,85] = 9.45, p < 0.001) followed by Bonferroni’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, n.s., not significant. Data are mean ± S.E.M.
Clozapine Noxide (Cno, supplied by Enzo Biochem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/strain+background+(+m%2E+musculus+)+%2C+dat-cre/clozapine+n+oxide++cno/10__7554_slash_elife__44928-270-206-209
Average 90 stars, based on 1 article reviews
clozapine-noxide (cno - by Bioz Stars, 2026-10
90/100 stars
  Buy from Supplier
ketamin  (Vetoquinol sa)
90
Vetoquinol sa ketamin
Serotonin 5-HT 2A R in DRG neurons represses oxycodone-induced antinociception in male mice. ( A ) Restoration of 5-HT 2A R expression in DRG neurons of 5-HT 2A R −/− male mice. By insertion of a “stop” cassette 5’ upstream of exon 1 (grey box) flanked by loxP sites (red arrows), we interrupted the translation of the 5-HT 2A R gene. Pirt-Cre excises the stop cassette and restores expression of 5-HT 2A R to areas where their promoter activities overlap. ( B ) Representative immunohistochemical images with anti-5-HT 2A R antibody and HRP-conjugated secondary antibody in DRG tissue samples of 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice. Note that 5-HT 2A R immunoreactivity is rescued in the DRG of 5-HT 2A R −/− :Pirt-Cre male mice. ( C ) Adjunctive effect of volinanserin (0.125 mg/kg) or vehicle on the cumulative dose-response induced by oxycodone in the TFR test in male 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice (n = 10-12 mice per group) (Oxycodone effect F[7,244] = 90.34, p < 0.001, Volinanserin/Genotype effect F[4,244] = 6.90, p < 0.01). ( D and E ) Male 5-H 2A R −/− <t>:Emx1-Cre</t> , 5-HT 2A R −/− :DAT-Cre and 5-HT 2A R −/− mice were given oxycodone (8 mg/kg), volinanserin (0.125 mg/kg) and oxycodone, or vehicle once a day for 5 days, after which locomotor activity was evaluated. On day 8 (3 days after the last injection), all mice received a single dose of oxycodone (8 mg/kg), and then tested for locomotor activity (n = 9-20 mice per group). Two-way ANOVA ( D – days 0-5, Time effect F[5,522] = 24.44, p < 0.001, Volinanserin/Oxycodone/Genotype effect F[5,522] = 39.77, p < 0.001) or one-way ANOVA ( D – day 8 and E , F[6,85] = 9.45, p < 0.001) followed by Bonferroni’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, n.s., not significant. Data are mean ± S.E.M.
Ketamin, supplied by Vetoquinol sa, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/strain+background+(+m%2E+musculus+)+%2C+dat-cre/ketamin/10__7554_slash_elife__72240-334-4-12
Average 90 stars, based on 1 article reviews
ketamin - by Bioz Stars, 2026-10
90/100 stars
  Buy from Supplier
xylazin hydrochlorine  (Provet NZ Pty Ltd)
90
Provet NZ Pty Ltd xylazin hydrochlorine
Serotonin 5-HT 2A R in DRG neurons represses oxycodone-induced antinociception in male mice. ( A ) Restoration of 5-HT 2A R expression in DRG neurons of 5-HT 2A R −/− male mice. By insertion of a “stop” cassette 5’ upstream of exon 1 (grey box) flanked by loxP sites (red arrows), we interrupted the translation of the 5-HT 2A R gene. Pirt-Cre excises the stop cassette and restores expression of 5-HT 2A R to areas where their promoter activities overlap. ( B ) Representative immunohistochemical images with anti-5-HT 2A R antibody and HRP-conjugated secondary antibody in DRG tissue samples of 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice. Note that 5-HT 2A R immunoreactivity is rescued in the DRG of 5-HT 2A R −/− :Pirt-Cre male mice. ( C ) Adjunctive effect of volinanserin (0.125 mg/kg) or vehicle on the cumulative dose-response induced by oxycodone in the TFR test in male 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice (n = 10-12 mice per group) (Oxycodone effect F[7,244] = 90.34, p < 0.001, Volinanserin/Genotype effect F[4,244] = 6.90, p < 0.01). ( D and E ) Male 5-H 2A R −/− <t>:Emx1-Cre</t> , 5-HT 2A R −/− :DAT-Cre and 5-HT 2A R −/− mice were given oxycodone (8 mg/kg), volinanserin (0.125 mg/kg) and oxycodone, or vehicle once a day for 5 days, after which locomotor activity was evaluated. On day 8 (3 days after the last injection), all mice received a single dose of oxycodone (8 mg/kg), and then tested for locomotor activity (n = 9-20 mice per group). Two-way ANOVA ( D – days 0-5, Time effect F[5,522] = 24.44, p < 0.001, Volinanserin/Oxycodone/Genotype effect F[5,522] = 39.77, p < 0.001) or one-way ANOVA ( D – day 8 and E , F[6,85] = 9.45, p < 0.001) followed by Bonferroni’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, n.s., not significant. Data are mean ± S.E.M.
Xylazin Hydrochlorine, supplied by Provet NZ Pty Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/strain+background+(+m%2E+musculus+)+%2C+dat-cre/xylazin+hydrochlorine/10__7554_slash_elife__72240-334-20-23
Average 90 stars, based on 1 article reviews
xylazin hydrochlorine - by Bioz Stars, 2026-10
90/100 stars
  Buy from Supplier

Image Search Results


Serotonin 5-HT 2A R in DRG neurons represses oxycodone-induced antinociception in male mice. ( A ) Restoration of 5-HT 2A R expression in DRG neurons of 5-HT 2A R −/− male mice. By insertion of a “stop” cassette 5’ upstream of exon 1 (grey box) flanked by loxP sites (red arrows), we interrupted the translation of the 5-HT 2A R gene. Pirt-Cre excises the stop cassette and restores expression of 5-HT 2A R to areas where their promoter activities overlap. ( B ) Representative immunohistochemical images with anti-5-HT 2A R antibody and HRP-conjugated secondary antibody in DRG tissue samples of 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice. Note that 5-HT 2A R immunoreactivity is rescued in the DRG of 5-HT 2A R −/− :Pirt-Cre male mice. ( C ) Adjunctive effect of volinanserin (0.125 mg/kg) or vehicle on the cumulative dose-response induced by oxycodone in the TFR test in male 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice (n = 10-12 mice per group) (Oxycodone effect F[7,244] = 90.34, p < 0.001, Volinanserin/Genotype effect F[4,244] = 6.90, p < 0.01). ( D and E ) Male 5-H 2A R −/− :Emx1-Cre , 5-HT 2A R −/− :DAT-Cre and 5-HT 2A R −/− mice were given oxycodone (8 mg/kg), volinanserin (0.125 mg/kg) and oxycodone, or vehicle once a day for 5 days, after which locomotor activity was evaluated. On day 8 (3 days after the last injection), all mice received a single dose of oxycodone (8 mg/kg), and then tested for locomotor activity (n = 9-20 mice per group). Two-way ANOVA ( D – days 0-5, Time effect F[5,522] = 24.44, p < 0.001, Volinanserin/Oxycodone/Genotype effect F[5,522] = 39.77, p < 0.001) or one-way ANOVA ( D – day 8 and E , F[6,85] = 9.45, p < 0.001) followed by Bonferroni’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, n.s., not significant. Data are mean ± S.E.M.

Journal: Neuropharmacology

Article Title: Sex-specific role for serotonin 5-HT 2A receptor in modulation of opioid-induced antinociception and reward in mice

doi: 10.1016/j.neuropharm.2022.108988

Figure Lengend Snippet: Serotonin 5-HT 2A R in DRG neurons represses oxycodone-induced antinociception in male mice. ( A ) Restoration of 5-HT 2A R expression in DRG neurons of 5-HT 2A R −/− male mice. By insertion of a “stop” cassette 5’ upstream of exon 1 (grey box) flanked by loxP sites (red arrows), we interrupted the translation of the 5-HT 2A R gene. Pirt-Cre excises the stop cassette and restores expression of 5-HT 2A R to areas where their promoter activities overlap. ( B ) Representative immunohistochemical images with anti-5-HT 2A R antibody and HRP-conjugated secondary antibody in DRG tissue samples of 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice. Note that 5-HT 2A R immunoreactivity is rescued in the DRG of 5-HT 2A R −/− :Pirt-Cre male mice. ( C ) Adjunctive effect of volinanserin (0.125 mg/kg) or vehicle on the cumulative dose-response induced by oxycodone in the TFR test in male 5-HT 2A R −/− and 5-HT 2A R −/− :Pirt-Cre mice (n = 10-12 mice per group) (Oxycodone effect F[7,244] = 90.34, p < 0.001, Volinanserin/Genotype effect F[4,244] = 6.90, p < 0.01). ( D and E ) Male 5-H 2A R −/− :Emx1-Cre , 5-HT 2A R −/− :DAT-Cre and 5-HT 2A R −/− mice were given oxycodone (8 mg/kg), volinanserin (0.125 mg/kg) and oxycodone, or vehicle once a day for 5 days, after which locomotor activity was evaluated. On day 8 (3 days after the last injection), all mice received a single dose of oxycodone (8 mg/kg), and then tested for locomotor activity (n = 9-20 mice per group). Two-way ANOVA ( D – days 0-5, Time effect F[5,522] = 24.44, p < 0.001, Volinanserin/Oxycodone/Genotype effect F[5,522] = 39.77, p < 0.001) or one-way ANOVA ( D – day 8 and E , F[6,85] = 9.45, p < 0.001) followed by Bonferroni’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, n.s., not significant. Data are mean ± S.E.M.

Article Snippet: Mice expressing a monomeric red fluorescent protein (mCherry) knocked into the last exon of μ-OR on a C57BL/6J background ( μ-OR-mCherry) (Stock No. 029013), Emx1-Cre mice (Stock No. 005628) and DAT-Cre mice (Stock No. 006660) on a C57BL/6J background were obtained from The Jackson Laboratory (Bar Harbor, ME).

Techniques: Expressing, Immunohistochemical staining, Activity Assay, Injection, Comparison